Safety data sheet 109122 microcrystalline cellulose 102 ph. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater. Microcrystalline cellulose 9004346 2326749 not listed dicalcium phosphate 7757939 2318261 not listed sodium starch glycolate 9063381 not listed not listed magnesium stearate 557040 2091503 not listed additional information. Microcrystalline cellulose is a commonly used excipient in the. Microcrystalline definition of microcrystalline by the free. Silicified microcrystalline cellulose pdf silicified microcrystalline cellulose smcc is a novel tableting excipient which. The microcrystalline cellulose monograph will be incorporated into and become official with the second supplement to the usp 42nf 37. Microcrystalline cellulose market size was usd 868. Microcrystalline cellulose is fully biodegradable and its products of degradation are more toxic. In case of skin contact wash off with soap and plenty.
Safety data sheet 109122 microcrystalline cellulose 102. Microcrystalline cellulose may create an allergic reaction in some patients, although there are few reported cases of this. Below is the msds for our cellulose acetate membrane membranes. All spectrum chemical nf grade products are manufactured, packaged and stored under current good manufacturing practice. Safety data sheet according to federal register vol. Safety data sheet in accordance with regulation eu no 4532010 109123 microcrystalline cellulose 112 ph. Microcrystalline cellulose microcrystalline cellulose mcc is an odorless, tasteless, porous white powder derived from pharmaceutical grade wood pulp.
Extraction and characterization of microcrystalline cellulose. Degree of polymerization, identification c nmt 350 units. Ribbons do not stick to the compaction rolls during roller compaction and dry granulation can be used in formulations with a high drug dosage. If inhaled if breathed in, move person into fresh air. In large quantities it provides dietary bulk and may lead to a laxative effect.
As early as 1969, safanova and klenkova had described the heterogeneous benzoylation of microcrystalline cellulose. Material safety data sheet hydroxypropyl methylcellulose. Methods and material for containment and cleaning up. Microcrystalline cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Should you have any questions about the microcrystalline cellulose monograph, please contact dr. Microcrystalline cellulose has many uses but its main use is as an excipient in the pharmaceutical industry as a binder in tablet formation. The results of xrd and raman analysis combined with curvefitting method show that the content of ordered carbon microcrystalline structure in beta3p is higher than the contents of other two samples, and beta2p has the lowest content of this microcrystalline structure. Pharmacel 101 microcrystalline cellulose mcc is also an ideal excipient for use in dry granulated formulations. Place about 10 mg of microcrystalline cellulose on a watch glass, and disperse in 2 ml of iodinated zinc chloride solution. Microcrystalline cellulose has no taste or flavor, so supplements that contain microcrystalline cellulose are easily taken. The unusual properties of microcrystalline cellulose as a potential stabiliser and fat mimetic were first studied by dr battista at the american viscose corporation in 1957 alexander, 1979. With a wide range of chemical, technical, and economic benefits, mcc is one of the most widely used binder excipients for tablet formulations. Nowadays, a methanolwater solution containing about 40% of the.
Microcrystalline cellulose avicel, fmc corporation is prepared by acid hydrolysis of cellulose using 2 m hydrochloric acid at 105 c for 15 min. Sigmaaldrich offers a number of microcrystalline cellulose products. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Shangraw t h e development of microcrystalline cellulose has made available t o the pharmaceutical industry an extremely valuable tableting agent. As a boundless renewable resource, cellulose has a potential on producing environmental friendly and biocompatible products. Pdf optimization of the isolation of nanocrystals from.
We make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Microcrystalline cellulose 9004346 1540 amoxicillin trihydrate 636707 1555 potassium clavulanate clavulanic 61177455 acid 420 dosedependent in accordance with 29 cfr 1910. Damp cellulose can be a significant fire hazard since it may undergo spontaneous combustion. Material safety data sheet carboxymethyl cellulose, sodium salt, average mw 90. Cellulose powder material safety data sheet sdsmsds. If breathing is irregular or stops, perform artificial respiration.
Not more than 10% of the particles have a diameter below 5. The degree of polymerization is typically less than 400. Nonwood fibre production of microcrystalline cellulose from. Microcrystalline cellulose, nf is an excipient in pharmaceutical formulations acting as a binder in tablet formation. Jul 17, 2015 microcrystalline cellulose e460 is used as a texturizer, an anticaking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Material safety data sheet cellulose curran cellucomp. Microcrystalline cellulose mcc is a term for refined wood pulp and is used as a texturizer, an anticaking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Microcrystalline cellulose prepared at the 55th jecfa 2000 and published in fnp52 add 8 2000, superseding specifications prepared at the 51st jecfa 1998 and published in fnp 52 add 6 1998. Microcrystalline cellulose side effects, side effects of.
Safety data sheet according to 29cfr19101200 and ghs rev. Microcrystalline cellulose is negative in the ames mutagenicity assay, and caused no chromosome damage in the mouse micronucleus assay. Pdf microcrystalline cellulose, a direct compression. Material safety data sheet carboxymethyl cellulose, sodium. Microcrystalline cellulose an overview sciencedirect topics. Microcrystalline cellulose mcc market size statistics 2026. The different investigated types of cellulose displayed different behavior during the extrusionspheronization process. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems.
This product has been classified in accordance with the hazard criteria of the cpr and the msds contains all of the information required by the cpr. You can download a pdf formatted copy in adobe acrobat26. The most common form is used in vitamin supplements or tablets. However, the data is provided without any warranty, expressed or implied, regarding its correctness or. In this study, the microcrystalline cellulose, obtained from the stalk of sorghum caudatum was evaluated for its physical and tableting characteristics. Common name microcrystalline cellulose formula c 6 h 10 o 5n cas number 9004346 section 4. Properties of microcrystalline cellulose and powder cellulose. Cellulose microcrystalline cas 9004346 msds download.
For dry granulation pharmacel 101 opens up vital production synergies. Cellulose microcrystalline, powder cotton linters sigma. A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. The new usp microcrystalline cellullose monograph pdf download available united states pharmacopoeia the revision to the harmonized standard for microcrystalline cellullose has been approved by the pharmacopeial discussion group pdg as described in its pdg signoff cover sheet. Microcrystalline cellulose is also used to prevent thickening in many food products due to its texture and chemical makeup. Get medical attention for any breathing difficulty.
This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates. All spectrum chemical nf grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Prepare iodinated zinc chloride solution by dissolving 20 g of zinc chloride and 6. Articles of cellulose microcrystalline are included as well. Cellulose powder cas no 9004346 material safety data. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. Material safety data sheet microcrystalline cellulose mcc msds 1. Fire fighting measures suitable extinguish media water, foam and. Preparation this msds has been prepared to meet the requirements of the brazilian regulatory standard 147254. Microcrystalline cellulose is purified, potentially polymerized cellulose prepared by treating alpha cellulose obtained as pulp from fibrous plant material with mineral acid.
Proprietary ingredients indicated as hazardous have been assessed under standards for workplace. Cellulose microcrystalline cas 9004346 msds guidechem. The information in this microcrystalline cellulose e460 msds was obtained from current and reliable sources. Safety data sheet molecular weight 160 000 560 000 chemical name cas number % by weight cellulose 9004346 100 composition there are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as health hazards and hence require reporting in this section. Cellulose, a glucan polymer that made up from dglucopyranose units and joined together by. Safety data sheet northwest missouri state university. Microcrystalline cellulose mcc, a type of cellulose that has undergone purification and partial hydrolyzation, is widely used in several industries including food production, beverage. It was found that tablets of plain microcrystalline cellulose will tend to soften and swell when exposed t o humid conditions, but the effect is reversed upon the removal of increased humidities. Avantor is a trusted global partner to customers and suppliers in the life science, advanced technology and applied materials industries. In this study, the effect of powder cellulose pc and 2 types of microcrystalline cellulose mcc 101 and mcc 301 on pellet properties produced by an extrusionspheronization process was investigated. Magnesium stearate compared with conventional microcrystalline cellulose.
Microcrystalline cellulose, nf 9004346 c1679 spectrum. The new usp microcrystalline cellullose monograph pdf. Technoeconomic analysis of simplified microcrystalline. Cellulose microcrystalline msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Msds hydroxypropyl methylcellulose, ohs11284, cas 9004653 mdl data bank, revision date december 9, 1997. Microcrystalline cellulose mcc i s pure partially depolymerized cellulose synthesized from. The mcc can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion and acid hydrolysis. Avicel rccl microcrystalline cellulose and sodiumcarboxymethylcellulose safety data sheet download 595756 msds ghsclp. Material safety data sheet nitrocellulose membrane filter. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication.
An adi not specified was established at the 49th jecfa 1998. Cellulose microcrystalline revision date 29jun2018 sara 3112 hazard categoriessee section 2 for more information cwa clean water act not applicable clean air act not applicable osha occupational safety and health administration not applicable cercla not applicable california proposition 65 this product does not contain any proposition 65 chemicals. Cellulose microcrystalline for thin layer chromatography. Though its considered safe, some are convinced it has potentially dangerous health effects. Portions of this monograph that are national usp text, and are not part of the harmonized text, are marked with symbols to specify this fact. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. The microcrystalline cellulose is an important ingredient in pharmaceutical, food, cosmetic and other industries.
We operate in more than 30 countries and deliver an extensive portfolio of mission critical products, services and solutions. Certificate of analysis coa specification sheet pdf raman ftir pdf similar products. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in. Because the substance is not absorbed, symptoms of allergic reaction are likely to be limited to gastrointestinal symptoms such as diarrhea or gas. Show this safety data sheet to the doctor in attendance. The powdered grades, first marketed in 1961, were originally used as sources of fibre in lowcalorie foods but later found wide acceptance within the. Its versatility in direct compression extends to very high dose actives, where compactability is at a premium. The objective of this work was to find a rapid, highyield process to obtain an aqueous stable colloid suspension of cellulose nanocrystalswhiskers. Photographs of microcrystalline cellulose sample separated from cotton waste ii sort lint at the same time, also the microcrystalline structure of mcc is well visible. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith. Technoeconomic analysis of simplified microcrystalline cellulose process kari m. Classification according to regulation ec no 12722008. Microcrystalline cellulose an overview sciencedirect.
Microcel microcrystalline cellulose mcc recommended use of the chemical. Carcinogenic categories iarc international agency for research on cancer. Material safety data sheet avicel ph microcrystalline cellulose msds ref. Microcrystalline cellulose msds, microcrystalline cellulose. Trademark cpr and the msds contains all the information required by the cpr. Carboxymethyl cellulose msds pdf aqualon cmc 7l sodium carboxymethylcellulose. Microcrystalline cellulose is basically cellulose and can only be derived from a specialized grade of alpha cellulose from fibrous. Microcrystalline cellulose is considered an inert dust, which is not toxic to the lung when exposures are properly contr are known. Cellulose microcrystalline for thinlayer chromatography. Trademark, ashland or its subsidiaries, registered in various. Microcrystalline cellulose is often used in whey protein powders and drinks containing whey. Micro crystalline cellulose material safety data sheet this document has been prepared to meet the requirements of the u. The side effects of microcrystalline cellulose synonym. Find msds or sds, a coa, data sheets and more information.
Microcrystalline cellulose in tableting pdf free download. In case of skin contact wash off with soap and plenty of water. The later process can be done using mineral acids such as h. Thus, data of mcc morphology of surface confirm the destruction of amorphous fraction of cellulose fibers by means of hydrolysis, and cellulose material turns into a high. The hazards presented for pulp, cellulose, pertain to dustparticulate.
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